Masaomi Nangaku Selected Research

Reperfusion Injury

11/2020	Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration.
1/2020	Recombinant thrombomodulin prevents acute lung injury induced by renal ischemia-reperfusion injury.
1/2020	Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage.
10/2019	Recombinant Thrombomodulin on Neutrophil Extracellular Traps in Murine Intestinal Ischemia-Reperfusion.
1/2019	ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis.
1/2019	Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney.
1/2019	Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia/reperfusion injury.
1/2017	Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
12/2013	Protection of glucagon-like peptide-1 in cisplatin-induced renal injury elucidates gut-kidney connection.
4/2013	Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice.

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Masaomi Nangaku Research Topics

Disease

107	Hypoxia (Hypoxemia) 09/2022 - 07/2003
71	Chronic Renal Insufficiency 12/2022 - 05/2006
52	Anemia 12/2022 - 01/2006
32	Proteinuria 01/2022 - 10/2001
29	Diabetic Nephropathies (Diabetic Nephropathy) 09/2022 - 01/2002
27	Neoplasms (Cancer) 12/2022 - 02/2008
27	Acute Kidney Injury (Acute Renal Failure) 10/2022 - 03/2004
23	Fibrosis (Cirrhosis) 01/2021 - 04/2002
22	Type 2 Diabetes Mellitus (MODY) 06/2022 - 04/2008
21	Inflammation (Inflammations) 09/2022 - 07/2006
19	Kidney Diseases (Kidney Disease) 03/2022 - 10/2008
16	Albuminuria 09/2022 - 08/2011
16	Chronic Kidney Failure (Chronic Renal Failure) 01/2022 - 01/2002
14	Hypertension (High Blood Pressure) 01/2020 - 05/2003
13	Reperfusion Injury 11/2020 - 03/2004
13	Ischemia 01/2020 - 03/2004
12	Renal Insufficiency (Renal Failure) 06/2022 - 06/2004
11	Infections 12/2021 - 02/2014
10	Atypical Hemolytic Uremic Syndrome 01/2022 - 01/2014
9	Glomerulonephritis 01/2022 - 01/2002
9	Body Weight (Weight, Body) 01/2022 - 12/2005
9	Thrombotic Microangiopathies 01/2020 - 10/2001
9	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2017 - 12/2004
8	Cardiovascular Diseases (Cardiovascular Disease) 05/2022 - 06/2006
8	Diabetes Mellitus 03/2022 - 01/2015
8	Heart Failure 06/2020 - 10/2012
7	Sepsis (Septicemia) 07/2020 - 01/2014
6	Hyperglycemia 01/2021 - 12/2005
6	Obesity 01/2020 - 12/2005
6	Membranous Glomerulonephritis (Membranous Nephropathy) 02/2018 - 05/2005
6	Nephritis 04/2015 - 01/2002
5	Critical Illness (Critically Ill) 08/2020 - 01/2016
5	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2020 - 07/2012
5	Thrombosis (Thrombus) 01/2020 - 10/2001
4	COVID-19 05/2022 - 08/2020
4	Edema (Dropsy) 01/2022 - 01/2011
4	Diarrhea 12/2021 - 12/2016
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 01/2019
4	Ascites 02/2020 - 02/2014
4	Insulin Resistance 01/2020 - 01/2015

Drug/Important Bio-Agent (IBA)

29	Prolyl-Hydroxylase InhibitorsIBA 09/2022 - 12/2007
27	Oxygen (Dioxygen)IBA 01/2022 - 01/2004
25	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2002
21	Erythropoietin FDA Link 01/2021 - 01/2006
20	CreatinineIBA 07/2022 - 08/2011
18	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2021 - 01/2006
17	Glucose (Dextrose)FDA LinkGeneric 07/2022 - 05/2003
16	HematinicsIBA 02/2022 - 08/2013
16	Complement System Proteins (Complement)IBA 01/2022 - 01/2002
15	Hemoglobins (Hemoglobin)IBA 01/2022 - 07/2006
15	Pharmaceutical PreparationsIBA 01/2022 - 02/2008
13	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 12/2004
12	enarodustatIBA 04/2022 - 01/2019
11	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2014
11	Transcription Factors (Transcription Factor)IBA 02/2021 - 11/2005
10	Darbepoetin alfa (Aranesp)FDA Link 02/2021 - 01/2015
9	Advanced Glycation End ProductsIBA 09/2022 - 10/2002
9	AlbuminsIBA 07/2022 - 03/2008
9	SodiumIBA 07/2022 - 09/2011
9	Messenger RNA (mRNA)IBA 01/2019 - 04/2004
8	IronIBA 12/2021 - 12/2005
7	GSK1278863IBA 12/2022 - 01/2017
7	RNA (Ribonucleic Acid)IBA 10/2022 - 01/2002
7	EnzymesIBA 10/2019 - 02/2008
6	Antihypertensive Agents (Antihypertensives)IBA 07/2022 - 05/2003
6	Sodium-Glucose Transporter 2 InhibitorsIBA 07/2022 - 01/2019
6	Dipeptidyl-Peptidase IV InhibitorsIBA 05/2022 - 09/2011
6	CytokinesIBA 01/2022 - 01/2011
6	Blood Glucose (Blood Sugar)IBA 01/2021 - 08/2011
6	Lipocalin-2IBA 08/2020 - 11/2013
6	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 05/2013
6	CobaltIBA 01/2018 - 07/2003
6	ElementsIBA 11/2011 - 12/2004
5	empagliflozinIBA 06/2022 - 05/2019
5	Insulin (Novolin)FDA Link 02/2022 - 05/2003
5	vadadustatIBA 02/2022 - 07/2020
5	Fibroblast Growth Factor-23IBA 01/2022 - 01/2017
5	Small Interfering RNA (siRNA)IBA 12/2020 - 08/2015
5	Histones (Histone)IBA 01/2020 - 01/2011
5	eculizumab FDA Link 04/2019 - 07/2016
5	SteroidsIBA 12/2017 - 10/2014
5	cobaltous chloride (cobalt(II)chloride)IBA 04/2017 - 11/2011
5	Angiotensin IIIBA 01/2015 - 02/2004
4	bardoxolone methylIBA 09/2022 - 10/2019
4	PotassiumIBA 07/2022 - 04/2017
4	esaxerenoneIBA 07/2022 - 01/2019
4	Phosphates (Orthophosphate)IBA 01/2022 - 01/2017
4	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2022 - 07/2015
4	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 11/2005
4	Interleukin-6 (Interleukin 6)IBA 07/2020 - 12/2014
4	ChloridesIBA 05/2020 - 05/2014
4	Urea (Carbamide)FDA LinkGeneric 01/2020 - 10/2001
4	Streptozocin (Streptozotocin)FDA Link 01/2020 - 05/2006

Therapy/Procedure

48	Therapeutics 07/2022 - 04/2003
23	Renal Dialysis (Hemodialysis) 04/2022 - 04/2003
10	Peritoneal Dialysis 12/2021 - 09/2005
6	Plasma Exchange 04/2019 - 07/2006
5	Catheters 12/2021 - 10/2020
5	Kidney Transplantation 03/2020 - 03/2004
5	Continuous Renal Replacement Therapy 01/2019 - 04/2015